AustralieFrV1, Main, Exploration, bibRecord, 000071

Veliparib With Temozolomide or Carboplatin/Paclitaxel Versus Placebo With Carboplatin/Paclitaxel in Patients With BRCA1/2 Locally Recurrent/Metastatic Breast Cancer: Randomized Phase II Study.

Identifieur interne : 000071 ( Main/Exploration ); précédent : 000070; suivant : 000072

Veliparib With Temozolomide or Carboplatin/Paclitaxel Versus Placebo With Carboplatin/Paclitaxel in Patients With BRCA1/2 Locally Recurrent/Metastatic Breast Cancer: Randomized Phase II Study.

Auteurs : H S Han [États-Unis] ; V. Diéras [France] ; M. Robson [États-Unis] ; M. Palácová [République tchèque] ; P K Marcom [États-Unis] ; A. Jager [Pays-Bas] ; I. Bondarenko [Ukraine] ; D. Citrin [États-Unis] ; M. Campone [France] ; M L Telli [États-Unis] ; S M Domchek [États-Unis] ; M. Friedlander [Australie] ; B. Kaufman [Israël] ; J E Garber [États-Unis] ; Y. Shparyk [Ukraine] ; E. Chmielowska [Pologne] ; E H Jakobsen [Danemark] ; V. Kaklamani [États-Unis] ; W. Gradishar [États-Unis] ; C K Ratajczak [États-Unis] ; C. Nickner [États-Unis] ; Q. Qin [États-Unis] ; J. Qian [États-Unis] ; S P Shepherd [États-Unis] ; S J Isakoff [États-Unis] ; S. Puhalla [États-Unis]

Source :

Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2017.

RBID : pubmed:29045554

Abstract

Homologous recombination defects in BRCA1/2-mutated tumors result in sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors, which interfere with DNA damage repair. Veliparib, a potent PARP inhibitor, enhanced the antitumor activity of platinum agents and temozolomide in early phase clinical trials. This phase II study examined the safety and efficacy of intermittent veliparib with carboplatin/paclitaxel (VCP) or temozolomide (VT) in patients with BRCA1/2-mutated breast cancer.

DOI: 10.1093/annonc/mdx505
PubMed: 29045554

Affiliations:

Australie, Danemark, France, Israël, Pays-Bas, Pologne, République tchèque, Ukraine, États-Unis
Californie, Caroline du Nord, Floride, Hollande-Méridionale, Illinois, Massachusetts, Moravie, Pennsylvanie, Texas, État de New York, Île-de-France
Brno, Paris, Rotterdam

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Veliparib With Temozolomide or Carboplatin/Paclitaxel Versus Placebo With Carboplatin/Paclitaxel in Patients With BRCA1/2 Locally Recurrent/Metastatic Breast Cancer: Randomized Phase II Study.</title>
<author><name sortKey="Han, H S" sort="Han, H S" uniqKey="Han H" first="H S" last="Han">H S Han</name>
<affiliation wicri:level="2"><nlm:affiliation>Moffitt Cancer Center, Tampa, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Moffitt Cancer Center, Tampa</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dieras, V" sort="Dieras, V" uniqKey="Dieras V" first="V" last="Diéras">V. Diéras</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Curie, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Curie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Robson, M" sort="Robson, M" uniqKey="Robson M" first="M" last="Robson">M. Robson</name>
<affiliation wicri:level="2"><nlm:affiliation>Weill Cornell Medical College, New York, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Palacova, M" sort="Palacova, M" uniqKey="Palacova M" first="M" last="Palácová">M. Palácová</name>
<affiliation wicri:level="3"><nlm:affiliation>Masarykuv onkologický ústav, Brno, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Masarykuv onkologický ústav, Brno</wicri:regionArea>
<placeName><settlement type="city">Brno</settlement>
<region>Moravie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marcom, P K" sort="Marcom, P K" uniqKey="Marcom P" first="P K" last="Marcom">P K Marcom</name>
<affiliation wicri:level="2"><nlm:affiliation>Duke University; Durham, NC.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Duke University; Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jager, A" sort="Jager, A" uniqKey="Jager A" first="A" last="Jager">A. Jager</name>
<affiliation wicri:level="3"><nlm:affiliation>Erasmus MC Cancer Institute, Rotterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bondarenko, I" sort="Bondarenko, I" uniqKey="Bondarenko I" first="I" last="Bondarenko">I. Bondarenko</name>
<affiliation wicri:level="1"><nlm:affiliation>Dnepropetrovsk Medical Academy, City Hospital #4, Dnipro, Ukraine.</nlm:affiliation>
<country xml:lang="fr">Ukraine</country>
<wicri:regionArea>Dnepropetrovsk Medical Academy, City Hospital #4, Dnipro</wicri:regionArea>
<wicri:noRegion>Dnipro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Citrin, D" sort="Citrin, D" uniqKey="Citrin D" first="D" last="Citrin">D. Citrin</name>
<affiliation wicri:level="2"><nlm:affiliation>Midwestern Regional Medical Center, Zion, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Midwestern Regional Medical Center, Zion</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Campone, M" sort="Campone, M" uniqKey="Campone M" first="M" last="Campone">M. Campone</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut de Cancérologie de l'Ouest, Saint Herblain, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Cancérologie de l'Ouest, Saint Herblain</wicri:regionArea>
<wicri:noRegion>Saint Herblain</wicri:noRegion>
<wicri:noRegion>Saint Herblain</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Telli, M L" sort="Telli, M L" uniqKey="Telli M" first="M L" last="Telli">M L Telli</name>
<affiliation wicri:level="2"><nlm:affiliation>Stanford University School of Medicine, Stanford, CA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Stanford University School of Medicine, Stanford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Domchek, S M" sort="Domchek, S M" uniqKey="Domchek S" first="S M" last="Domchek">S M Domchek</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Pennsylvania, Philadelphia, PA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Friedlander, M" sort="Friedlander, M" uniqKey="Friedlander M" first="M" last="Friedlander">M. Friedlander</name>
<affiliation wicri:level="1"><nlm:affiliation>Prince of Wales Hospital, Sydney, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Prince of Wales Hospital, Sydney, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaufman, B" sort="Kaufman, B" uniqKey="Kaufman B" first="B" last="Kaufman">B. Kaufman</name>
<affiliation wicri:level="1"><nlm:affiliation>Sheba Medical Center, Tel Hashomer, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Sheba Medical Center, Tel Hashomer</wicri:regionArea>
<wicri:noRegion>Tel Hashomer</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garber, J E" sort="Garber, J E" uniqKey="Garber J" first="J E" last="Garber">J E Garber</name>
<affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shparyk, Y" sort="Shparyk, Y" uniqKey="Shparyk Y" first="Y" last="Shparyk">Y. Shparyk</name>
<affiliation wicri:level="1"><nlm:affiliation>Chemotherapy Department, Lviv State Regional Treatment and Diagnostics Oncology Center, Lviv, Ukraine.</nlm:affiliation>
<country xml:lang="fr">Ukraine</country>
<wicri:regionArea>Chemotherapy Department, Lviv State Regional Treatment and Diagnostics Oncology Center, Lviv</wicri:regionArea>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chmielowska, E" sort="Chmielowska, E" uniqKey="Chmielowska E" first="E" last="Chmielowska">E. Chmielowska</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Oncology Centre, Bydgoszcz, UMK, Torun, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Clinical Oncology, Oncology Centre, Bydgoszcz, UMK, Torun</wicri:regionArea>
<wicri:noRegion>Torun</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jakobsen, E H" sort="Jakobsen, E H" uniqKey="Jakobsen E" first="E H" last="Jakobsen">E H Jakobsen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Vejle Hospital/Lillebaelt Hospital, Vejle, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Oncology, Vejle Hospital/Lillebaelt Hospital, Vejle</wicri:regionArea>
<wicri:noRegion>Vejle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaklamani, V" sort="Kaklamani, V" uniqKey="Kaklamani V" first="V" last="Kaklamani">V. Kaklamani</name>
<affiliation wicri:level="2"><nlm:affiliation>Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gradishar, W" sort="Gradishar, W" uniqKey="Gradishar W" first="W" last="Gradishar">W. Gradishar</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ratajczak, C K" sort="Ratajczak, C K" uniqKey="Ratajczak C" first="C K" last="Ratajczak">C K Ratajczak</name>
<affiliation wicri:level="2"><nlm:affiliation>AbbVie Inc., North Chicago, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>AbbVie Inc., North Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nickner, C" sort="Nickner, C" uniqKey="Nickner C" first="C" last="Nickner">C. Nickner</name>
<affiliation wicri:level="2"><nlm:affiliation>AbbVie Inc., North Chicago, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>AbbVie Inc., North Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Qin, Q" sort="Qin, Q" uniqKey="Qin Q" first="Q" last="Qin">Q. Qin</name>
<affiliation wicri:level="2"><nlm:affiliation>AbbVie Inc., North Chicago, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>AbbVie Inc., North Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Qian, J" sort="Qian, J" uniqKey="Qian J" first="J" last="Qian">J. Qian</name>
<affiliation wicri:level="2"><nlm:affiliation>AbbVie Inc., North Chicago, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>AbbVie Inc., North Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shepherd, S P" sort="Shepherd, S P" uniqKey="Shepherd S" first="S P" last="Shepherd">S P Shepherd</name>
<affiliation wicri:level="2"><nlm:affiliation>AbbVie Inc., North Chicago, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>AbbVie Inc., North Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Isakoff, S J" sort="Isakoff, S J" uniqKey="Isakoff S" first="S J" last="Isakoff">S J Isakoff</name>
<affiliation wicri:level="2"><nlm:affiliation>Massachusetts General Hospital, Boston, MA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Puhalla, S" sort="Puhalla, S" uniqKey="Puhalla S" first="S" last="Puhalla">S. Puhalla</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Cancer Institute, Pittsburgh, PA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:29045554</idno>
<idno type="pmid">29045554</idno>
<idno type="doi">10.1093/annonc/mdx505</idno>
<idno type="wicri:Area/PubMed/Corpus">000451</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000451</idno>
<idno type="wicri:Area/PubMed/Curation">000449</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000449</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000449</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000449</idno>
<idno type="wicri:Area/Ncbi/Merge">005059</idno>
<idno type="wicri:Area/Ncbi/Curation">005059</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">005059</idno>
<idno type="wicri:Area/Main/Merge">000066</idno>
<idno type="wicri:Area/Main/Curation">000071</idno>
<idno type="wicri:Area/Main/Exploration">000071</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Veliparib With Temozolomide or Carboplatin/Paclitaxel Versus Placebo With Carboplatin/Paclitaxel in Patients With BRCA1/2 Locally Recurrent/Metastatic Breast Cancer: Randomized Phase II Study.</title>
<author><name sortKey="Han, H S" sort="Han, H S" uniqKey="Han H" first="H S" last="Han">H S Han</name>
<affiliation wicri:level="2"><nlm:affiliation>Moffitt Cancer Center, Tampa, FL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Moffitt Cancer Center, Tampa</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dieras, V" sort="Dieras, V" uniqKey="Dieras V" first="V" last="Diéras">V. Diéras</name>
<affiliation wicri:level="3"><nlm:affiliation>Institut Curie, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Curie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Robson, M" sort="Robson, M" uniqKey="Robson M" first="M" last="Robson">M. Robson</name>
<affiliation wicri:level="2"><nlm:affiliation>Weill Cornell Medical College, New York, NY.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Weill Cornell Medical College, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Palacova, M" sort="Palacova, M" uniqKey="Palacova M" first="M" last="Palácová">M. Palácová</name>
<affiliation wicri:level="3"><nlm:affiliation>Masarykuv onkologický ústav, Brno, Czech Republic.</nlm:affiliation>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Masarykuv onkologický ústav, Brno</wicri:regionArea>
<placeName><settlement type="city">Brno</settlement>
<region>Moravie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marcom, P K" sort="Marcom, P K" uniqKey="Marcom P" first="P K" last="Marcom">P K Marcom</name>
<affiliation wicri:level="2"><nlm:affiliation>Duke University; Durham, NC.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Duke University; Durham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jager, A" sort="Jager, A" uniqKey="Jager A" first="A" last="Jager">A. Jager</name>
<affiliation wicri:level="3"><nlm:affiliation>Erasmus MC Cancer Institute, Rotterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bondarenko, I" sort="Bondarenko, I" uniqKey="Bondarenko I" first="I" last="Bondarenko">I. Bondarenko</name>
<affiliation wicri:level="1"><nlm:affiliation>Dnepropetrovsk Medical Academy, City Hospital #4, Dnipro, Ukraine.</nlm:affiliation>
<country xml:lang="fr">Ukraine</country>
<wicri:regionArea>Dnepropetrovsk Medical Academy, City Hospital #4, Dnipro</wicri:regionArea>
<wicri:noRegion>Dnipro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Citrin, D" sort="Citrin, D" uniqKey="Citrin D" first="D" last="Citrin">D. Citrin</name>
<affiliation wicri:level="2"><nlm:affiliation>Midwestern Regional Medical Center, Zion, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Midwestern Regional Medical Center, Zion</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Campone, M" sort="Campone, M" uniqKey="Campone M" first="M" last="Campone">M. Campone</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut de Cancérologie de l'Ouest, Saint Herblain, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Cancérologie de l'Ouest, Saint Herblain</wicri:regionArea>
<wicri:noRegion>Saint Herblain</wicri:noRegion>
<wicri:noRegion>Saint Herblain</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Telli, M L" sort="Telli, M L" uniqKey="Telli M" first="M L" last="Telli">M L Telli</name>
<affiliation wicri:level="2"><nlm:affiliation>Stanford University School of Medicine, Stanford, CA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Stanford University School of Medicine, Stanford</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Domchek, S M" sort="Domchek, S M" uniqKey="Domchek S" first="S M" last="Domchek">S M Domchek</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Pennsylvania, Philadelphia, PA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Friedlander, M" sort="Friedlander, M" uniqKey="Friedlander M" first="M" last="Friedlander">M. Friedlander</name>
<affiliation wicri:level="1"><nlm:affiliation>Prince of Wales Hospital, Sydney, NSW, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Prince of Wales Hospital, Sydney, NSW</wicri:regionArea>
<wicri:noRegion>NSW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaufman, B" sort="Kaufman, B" uniqKey="Kaufman B" first="B" last="Kaufman">B. Kaufman</name>
<affiliation wicri:level="1"><nlm:affiliation>Sheba Medical Center, Tel Hashomer, Israel.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Sheba Medical Center, Tel Hashomer</wicri:regionArea>
<wicri:noRegion>Tel Hashomer</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Garber, J E" sort="Garber, J E" uniqKey="Garber J" first="J E" last="Garber">J E Garber</name>
<affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shparyk, Y" sort="Shparyk, Y" uniqKey="Shparyk Y" first="Y" last="Shparyk">Y. Shparyk</name>
<affiliation wicri:level="1"><nlm:affiliation>Chemotherapy Department, Lviv State Regional Treatment and Diagnostics Oncology Center, Lviv, Ukraine.</nlm:affiliation>
<country xml:lang="fr">Ukraine</country>
<wicri:regionArea>Chemotherapy Department, Lviv State Regional Treatment and Diagnostics Oncology Center, Lviv</wicri:regionArea>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chmielowska, E" sort="Chmielowska, E" uniqKey="Chmielowska E" first="E" last="Chmielowska">E. Chmielowska</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Oncology Centre, Bydgoszcz, UMK, Torun, Poland.</nlm:affiliation>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Clinical Oncology, Oncology Centre, Bydgoszcz, UMK, Torun</wicri:regionArea>
<wicri:noRegion>Torun</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jakobsen, E H" sort="Jakobsen, E H" uniqKey="Jakobsen E" first="E H" last="Jakobsen">E H Jakobsen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Vejle Hospital/Lillebaelt Hospital, Vejle, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Oncology, Vejle Hospital/Lillebaelt Hospital, Vejle</wicri:regionArea>
<wicri:noRegion>Vejle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaklamani, V" sort="Kaklamani, V" uniqKey="Kaklamani V" first="V" last="Kaklamani">V. Kaklamani</name>
<affiliation wicri:level="2"><nlm:affiliation>Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gradishar, W" sort="Gradishar, W" uniqKey="Gradishar W" first="W" last="Gradishar">W. Gradishar</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ratajczak, C K" sort="Ratajczak, C K" uniqKey="Ratajczak C" first="C K" last="Ratajczak">C K Ratajczak</name>
<affiliation wicri:level="2"><nlm:affiliation>AbbVie Inc., North Chicago, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>AbbVie Inc., North Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nickner, C" sort="Nickner, C" uniqKey="Nickner C" first="C" last="Nickner">C. Nickner</name>
<affiliation wicri:level="2"><nlm:affiliation>AbbVie Inc., North Chicago, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>AbbVie Inc., North Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Qin, Q" sort="Qin, Q" uniqKey="Qin Q" first="Q" last="Qin">Q. Qin</name>
<affiliation wicri:level="2"><nlm:affiliation>AbbVie Inc., North Chicago, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>AbbVie Inc., North Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Qian, J" sort="Qian, J" uniqKey="Qian J" first="J" last="Qian">J. Qian</name>
<affiliation wicri:level="2"><nlm:affiliation>AbbVie Inc., North Chicago, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>AbbVie Inc., North Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shepherd, S P" sort="Shepherd, S P" uniqKey="Shepherd S" first="S P" last="Shepherd">S P Shepherd</name>
<affiliation wicri:level="2"><nlm:affiliation>AbbVie Inc., North Chicago, IL.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>AbbVie Inc., North Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Isakoff, S J" sort="Isakoff, S J" uniqKey="Isakoff S" first="S J" last="Isakoff">S J Isakoff</name>
<affiliation wicri:level="2"><nlm:affiliation>Massachusetts General Hospital, Boston, MA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Massachusetts General Hospital, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Puhalla, S" sort="Puhalla, S" uniqKey="Puhalla S" first="S" last="Puhalla">S. Puhalla</name>
<affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Cancer Institute, Pittsburgh, PA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>University of Pittsburgh Cancer Institute, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title>
<idno type="eISSN">1569-8041</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Homologous recombination defects in BRCA1/2-mutated tumors result in sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors, which interfere with DNA damage repair. Veliparib, a potent PARP inhibitor, enhanced the antitumor activity of platinum agents and temozolomide in early phase clinical trials. This phase II study examined the safety and efficacy of intermittent veliparib with carboplatin/paclitaxel (VCP) or temozolomide (VT) in patients with BRCA1/2-mutated breast cancer.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Danemark</li>
<li>France</li>
<li>Israël</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>République tchèque</li>
<li>Ukraine</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Caroline du Nord</li>
<li>Floride</li>
<li>Hollande-Méridionale</li>
<li>Illinois</li>
<li>Massachusetts</li>
<li>Moravie</li>
<li>Pennsylvanie</li>
<li>Texas</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement><li>Brno</li>
<li>Paris</li>
<li>Rotterdam</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Floride"><name sortKey="Han, H S" sort="Han, H S" uniqKey="Han H" first="H S" last="Han">H S Han</name>
</region>
<name sortKey="Citrin, D" sort="Citrin, D" uniqKey="Citrin D" first="D" last="Citrin">D. Citrin</name>
<name sortKey="Domchek, S M" sort="Domchek, S M" uniqKey="Domchek S" first="S M" last="Domchek">S M Domchek</name>
<name sortKey="Garber, J E" sort="Garber, J E" uniqKey="Garber J" first="J E" last="Garber">J E Garber</name>
<name sortKey="Gradishar, W" sort="Gradishar, W" uniqKey="Gradishar W" first="W" last="Gradishar">W. Gradishar</name>
<name sortKey="Isakoff, S J" sort="Isakoff, S J" uniqKey="Isakoff S" first="S J" last="Isakoff">S J Isakoff</name>
<name sortKey="Kaklamani, V" sort="Kaklamani, V" uniqKey="Kaklamani V" first="V" last="Kaklamani">V. Kaklamani</name>
<name sortKey="Marcom, P K" sort="Marcom, P K" uniqKey="Marcom P" first="P K" last="Marcom">P K Marcom</name>
<name sortKey="Nickner, C" sort="Nickner, C" uniqKey="Nickner C" first="C" last="Nickner">C. Nickner</name>
<name sortKey="Puhalla, S" sort="Puhalla, S" uniqKey="Puhalla S" first="S" last="Puhalla">S. Puhalla</name>
<name sortKey="Qian, J" sort="Qian, J" uniqKey="Qian J" first="J" last="Qian">J. Qian</name>
<name sortKey="Qin, Q" sort="Qin, Q" uniqKey="Qin Q" first="Q" last="Qin">Q. Qin</name>
<name sortKey="Ratajczak, C K" sort="Ratajczak, C K" uniqKey="Ratajczak C" first="C K" last="Ratajczak">C K Ratajczak</name>
<name sortKey="Robson, M" sort="Robson, M" uniqKey="Robson M" first="M" last="Robson">M. Robson</name>
<name sortKey="Shepherd, S P" sort="Shepherd, S P" uniqKey="Shepherd S" first="S P" last="Shepherd">S P Shepherd</name>
<name sortKey="Telli, M L" sort="Telli, M L" uniqKey="Telli M" first="M L" last="Telli">M L Telli</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Dieras, V" sort="Dieras, V" uniqKey="Dieras V" first="V" last="Diéras">V. Diéras</name>
</region>
<name sortKey="Campone, M" sort="Campone, M" uniqKey="Campone M" first="M" last="Campone">M. Campone</name>
</country>
<country name="République tchèque"><region name="Moravie"><name sortKey="Palacova, M" sort="Palacova, M" uniqKey="Palacova M" first="M" last="Palácová">M. Palácová</name>
</region>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Jager, A" sort="Jager, A" uniqKey="Jager A" first="A" last="Jager">A. Jager</name>
</region>
</country>
<country name="Ukraine"><noRegion><name sortKey="Bondarenko, I" sort="Bondarenko, I" uniqKey="Bondarenko I" first="I" last="Bondarenko">I. Bondarenko</name>
</noRegion>
<name sortKey="Shparyk, Y" sort="Shparyk, Y" uniqKey="Shparyk Y" first="Y" last="Shparyk">Y. Shparyk</name>
</country>
<country name="Australie"><noRegion><name sortKey="Friedlander, M" sort="Friedlander, M" uniqKey="Friedlander M" first="M" last="Friedlander">M. Friedlander</name>
</noRegion>
</country>
<country name="Israël"><noRegion><name sortKey="Kaufman, B" sort="Kaufman, B" uniqKey="Kaufman B" first="B" last="Kaufman">B. Kaufman</name>
</noRegion>
</country>
<country name="Pologne"><noRegion><name sortKey="Chmielowska, E" sort="Chmielowska, E" uniqKey="Chmielowska E" first="E" last="Chmielowska">E. Chmielowska</name>
</noRegion>
</country>
<country name="Danemark"><noRegion><name sortKey="Jakobsen, E H" sort="Jakobsen, E H" uniqKey="Jakobsen E" first="E H" last="Jakobsen">E H Jakobsen</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000071 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000071 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:29045554
   |texte=   Veliparib With Temozolomide or Carboplatin/Paclitaxel Versus Placebo With Carboplatin/Paclitaxel in Patients With BRCA1/2 Locally Recurrent/Metastatic Breast Cancer: Randomized Phase II Study.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:29045554" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Veliparib With Temozolomide or Carboplatin/Paclitaxel Versus Placebo With Carboplatin/Paclitaxel in Patients With BRCA1/2 Locally Recurrent/Metastatic Breast Cancer: Randomized Phase II Study.

Veliparib With Temozolomide or Carboplatin/Paclitaxel Versus Placebo With Carboplatin/Paclitaxel in Patients With BRCA1/2 Locally Recurrent/Metastatic Breast Cancer: Randomized Phase II Study.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.